ABSTRACT
This study describes the formulation of immediate release Ketorolac tromethamine (KT) 10-mg tablet by directcompression method; evaluation of their compliance to various Pharmacopoeial quality parameters, i.e., weightvariation, friability, hardness, thickness, moisture content, disintegration, assay, and dissolution; and their comparisonwith marketed brands for determination of pharmaceutical equivalency. Five formulations of KT were prepared(coded as FKT1, FKT2, FKT3, FKT4, and FKT5) by direct compression method using different superdisintegrants.Micrometric properties of the mixtures of the drug and the excipients prepared for formulation were evaluated. Qualityevaluation of the five different formulations and randomly selected four different brands of KT 10-mg tablets purchasedfrom the local market (coded as LKT1, MKT2, MKT3, and SKT4) were performed according to Pharmacopoeia. Theresults were obtained by UV-Vis spectrophotometer and all the dissolution profiles were characterized by the zeroorder kinetics. All the brands of KT and developed formulations met the official specification except SKT4 whichshowed excessive moisture content of 7.18%. None of the tested brands of KT were found to be pharmaceuticallyequivalent, whereas two developed formulation were pharmaceutically equivalent with the in house benchmark(MKT2) from which their interchangeability can be suggested.
ABSTRACT
Nymphoides is an aquatic genus consisting about 50 species,of which few were accepted as traditional medicinal plants in Asia.The literature review revealed that Nymphoides species are widely used in Ayurvedic medicine as a popular drug,i.e.Tagara.They are also utilized by the traditional local healers of different Asian countries to treat various diseases,like convulsion,jaundice,fever,headache,etc.According to thein vivo and in vitro pharmacological studies,Nymphoides species have been claimed to possess major biological activities like anticonvulsant,antioxidant,hepatoprotective,cytotoxic,antitumor,etc.Biochemical profiling of different aquatic plants of this genus revealed the presence of some important phytoehemicals as polyphenolic component,flavonoids,triterpenes,carbohydrates,glycosides,etc.Several valuable bioactive compounds including ephedrine,coumarin,secoiridoid glucosides,methyl quercetin,ferulic acid,follamenthoic acid,etc.were also known to be isolated and identified from different Nymphoides species.The aim of this review is to analyze the published report based on the medicinal values of different Asian Nymphoides species,to provide the updlated information about the ethnomedicinal,pharmacological as well as the phytochemical properties for the first time.
ABSTRACT
The research work was involved in rapid and efficient procedure for the attachment of barbituric acid with arylidene acetophenone under microwave irradiation (MWI) and conventional heating. The result showed that the time was reduced from the conventional 24 hours to 5-10 minutes. In conventional heating, the yield of the compounds 2a-2e were very poor (75-81%), but in MW methods the yields were observed 96.48-98% which was comparatively too high. The structures of the compounds were characterized by FT-IR, 1H-NMR spectral data. The antimicrobial and cytotoxic activities of the synthesized compounds were also investigated. Staphylococcus aureus, Bacillus megaterium, Escherichia coli and Pseudomonas aeruginosa revealed the zone of inhibition were 6-12 mm where sample concentration was 100 μg/disc. However, cytotoxic analysis, the mortality 47-95% were appeared when sample concentration were 0.78-25 (μg/ml) and more than 50 (μg/ml) concentration showed 100% mortality. The presence of a reactive and unsaturated ketone function in synthesized compounds was found to be responsible for their potential antimicrobial and cytotoxic activity.
ABSTRACT
Two tirucallane triterpenes, namely flindissol (1) and 3-oxotirucalla-7,24-dien-21-oic-acid (2), were isolated from the dichloromethane extract of the stem of Luvunga scandens (Roxb.) Buch-Ham ex Wight & Arn, Rutaceae. This is the first report of their isolation from this plant. Their structures were constructed by high resolution mass and 2D NMR spectroscopic data. The cytotoxic potential of the two pure compounds 1 and 2 were determined by MTT assay against human breast adenocarcinoma cell line (MCF-7). Compounds 1 and 2 showed potent cytotoxicity against MCF-7 cell line with IC50 values of 13.8 μM and 27.5 μM, respectively. This result suggested their potential activity as antitumor agents.